Early clinical experiences with the new influenza A (H1N1/09).
Identifieur interne : 000407 ( Main/Exploration ); précédent : 000406; suivant : 000408Early clinical experiences with the new influenza A (H1N1/09).
Auteurs : Ralf Winzer [Allemagne] ; Nicolas Kanig ; Sophie Schneitler ; Stefan Reuter ; Björn Jensen ; Irmela Müller-Stöver ; Jun Oh ; Ortwin Adams ; Ertan Mayatepek ; Hartmut Hengel ; Heiko Schneitler ; Dieter H UssingerSource :
- Deutsches Arzteblatt international [ 1866-0452 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allemagne (épidémiologie), Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Flambées de maladies (), Grippe humaine (épidémiologie), Humains, Incidence, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Répartition par âge, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population, Évaluation des risques ().
- MESH :
- épidémiologie : Allemagne, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Flambées de maladies, Humains, Incidence, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Répartition par âge, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population, Évaluation des risques.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Disease Outbreaks (statistics & numerical data), Female, Germany (epidemiology), Humans, Incidence, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype, Influenza, Human (epidemiology), Male, Middle Aged, Population Surveillance, Risk Assessment (methods), Risk Factors, Young Adult.
- MESH :
- geographic , epidemiology : Germany.
- epidemiology : Influenza, Human.
- methods : Risk Assessment.
- statistics & numerical data : Disease Outbreaks.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Incidence, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Population Surveillance, Risk Factors, Young Adult.
Abstract
BACKGROUND
Because of ongoing person-to-person transmission of the disease, the World Health Organization has declared a phase 6 pandemic alert for the new type of influenza A (H1N1/09). This means that the spread of the disease must be closely monitored.
METHODS
At the Düsseldorf University Hospital, patients with flu-like symptoms and their contacts have been tested for the new type of influenza A since April 2009.
RESULTS
The first patients that tested positive for H1N1/09 were treated on 20 May 2009. By mid-September, 3372 persons underwent PCR testing of a sample obtained by deep nasal swabbing, and the results were positive in 450 (13.3%). 379 of these 450 infections, or 84.2%, had been contracted abroad. Most patients came to the hospital with flu-like symptoms within three days of becoming ill. An analysis of the first 60 patients revealed a median core temperature of 37.8 degrees C and a mildly elevated C-reactive protein concentration. All patients were treated with oseltamivir. Most of the initially symptomatic patients were asymptomatic again within 3 days; the median duration of treatment was 5 days. The median time to the first negative deep nasal swab was 4 days. No oseltamivir resistance has been found to date in our patient collective.
CONCLUSION
The clinical manifestations of the new type of influenza were still mild in the patient population that we studied up to mid-September 2009. At that time, the second wave of the pandemic had not yet begun in Germany. At present, however, the number of cases acquired within the country is on the rise.
DOI: 10.3238/arztebl.2009.0770
PubMed: 20019861
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term><term>Population Surveillance</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Répartition par âge</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance de la population</term><term>Évaluation des risques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Because of ongoing person-to-person transmission of the disease, the World Health Organization has declared a phase 6 pandemic alert for the new type of influenza A (H1N1/09). This means that the spread of the disease must be closely monitored.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>At the Düsseldorf University Hospital, patients with flu-like symptoms and their contacts have been tested for the new type of influenza A since April 2009.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The first patients that tested positive for H1N1/09 were treated on 20 May 2009. By mid-September, 3372 persons underwent PCR testing of a sample obtained by deep nasal swabbing, and the results were positive in 450 (13.3%). 379 of these 450 infections, or 84.2%, had been contracted abroad. Most patients came to the hospital with flu-like symptoms within three days of becoming ill. An analysis of the first 60 patients revealed a median core temperature of 37.8 degrees C and a mildly elevated C-reactive protein concentration. All patients were treated with oseltamivir. Most of the initially symptomatic patients were asymptomatic again within 3 days; the median duration of treatment was 5 days. The median time to the first negative deep nasal swab was 4 days. No oseltamivir resistance has been found to date in our patient collective.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The clinical manifestations of the new type of influenza were still mild in the patient population that we studied up to mid-September 2009. At that time, the second wave of the pandemic had not yet begun in Germany. At present, however, the number of cases acquired within the country is on the rise.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20019861</PMID><DateCompleted><Year>2010</Year><Month>03</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1866-0452</ISSN><JournalIssue CitedMedium="Internet"><Volume>106</Volume><Issue>47</Issue><PubDate><Year>2009</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Deutsches Arzteblatt international</Title><ISOAbbreviation>Dtsch Arztebl Int</ISOAbbreviation></Journal><ArticleTitle>Early clinical experiences with the new influenza A (H1N1/09).</ArticleTitle><Pagination><MedlinePgn>770-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3238/arztebl.2009.0770</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Because of ongoing person-to-person transmission of the disease, the World Health Organization has declared a phase 6 pandemic alert for the new type of influenza A (H1N1/09). This means that the spread of the disease must be closely monitored.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">At the Düsseldorf University Hospital, patients with flu-like symptoms and their contacts have been tested for the new type of influenza A since April 2009.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The first patients that tested positive for H1N1/09 were treated on 20 May 2009. By mid-September, 3372 persons underwent PCR testing of a sample obtained by deep nasal swabbing, and the results were positive in 450 (13.3%). 379 of these 450 infections, or 84.2%, had been contracted abroad. Most patients came to the hospital with flu-like symptoms within three days of becoming ill. An analysis of the first 60 patients revealed a median core temperature of 37.8 degrees C and a mildly elevated C-reactive protein concentration. All patients were treated with oseltamivir. Most of the initially symptomatic patients were asymptomatic again within 3 days; the median duration of treatment was 5 days. The median time to the first negative deep nasal swab was 4 days. No oseltamivir resistance has been found to date in our patient collective.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The clinical manifestations of the new type of influenza were still mild in the patient population that we studied up to mid-September 2009. At that time, the second wave of the pandemic had not yet begun in Germany. At present, however, the number of cases acquired within the country is on the rise.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Winzer</LastName><ForeName>Ralf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Düsseldorf , Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanig</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Schneitler</LastName><ForeName>Sophie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Reuter</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Jensen</LastName><ForeName>Björn</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Müller-Stöver</LastName><ForeName>Irmela</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>Ortwin</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Mayatepek</LastName><ForeName>Ertan</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Hengel</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Schneitler</LastName><ForeName>Heiko</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Häussinger</LastName><ForeName>Dieter</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>11</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Dtsch Arztebl Int</MedlineTA><NlmUniqueID>101475967</NlmUniqueID><ISSNLinking>1866-0452</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Dtsch Arztebl Int. 2010 Apr;107(13):229-30; author reply 230</RefSource><PMID Version="1">20396519</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Dtsch Arztebl Int. 2010 Apr;107(13):229; author reply 230</RefSource><PMID Version="1">20396520</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011159" MajorTopicYN="Y">Population Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" 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de Düsseldorf</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Düsseldorf</li></settlement></list><tree><noCountry><name sortKey="Adams, Ortwin" sort="Adams, Ortwin" uniqKey="Adams O" first="Ortwin" last="Adams">Ortwin Adams</name><name sortKey="H Ussinger, Dieter" sort="H Ussinger, Dieter" uniqKey="H Ussinger D" first="Dieter" last="H Ussinger">Dieter H Ussinger</name><name sortKey="Hengel, Hartmut" sort="Hengel, Hartmut" uniqKey="Hengel H" first="Hartmut" last="Hengel">Hartmut Hengel</name><name sortKey="Jensen, Bjorn" sort="Jensen, Bjorn" uniqKey="Jensen B" first="Björn" last="Jensen">Björn Jensen</name><name sortKey="Kanig, Nicolas" sort="Kanig, Nicolas" uniqKey="Kanig N" first="Nicolas" last="Kanig">Nicolas Kanig</name><name sortKey="Mayatepek, Ertan" sort="Mayatepek, Ertan" uniqKey="Mayatepek E" first="Ertan" last="Mayatepek">Ertan Mayatepek</name><name sortKey="Muller Stover, Irmela" sort="Muller Stover, Irmela" uniqKey="Muller Stover I" first="Irmela" last="Müller-Stöver">Irmela Müller-Stöver</name><name sortKey="Oh, Jun" sort="Oh, Jun" uniqKey="Oh J" first="Jun" last="Oh">Jun Oh</name><name sortKey="Reuter, Stefan" sort="Reuter, Stefan" uniqKey="Reuter S" first="Stefan" last="Reuter">Stefan Reuter</name><name sortKey="Schneitler, Heiko" sort="Schneitler, Heiko" uniqKey="Schneitler H" first="Heiko" last="Schneitler">Heiko Schneitler</name><name sortKey="Schneitler, Sophie" sort="Schneitler, Sophie" uniqKey="Schneitler S" first="Sophie" last="Schneitler">Sophie Schneitler</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Winzer, Ralf" sort="Winzer, Ralf" uniqKey="Winzer R" first="Ralf" last="Winzer">Ralf Winzer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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